Solvent Modulation of Polysacharide Conformation
نویسندگان
چکیده
Polymers are widely used in solution to provide structure and function, e.g., viscoelasticity, colloidal stability, and delivery of actives. Underlying these functions are interand intra-molecular interactions that are modulated by the solvent used. Solvents can have a great impact on polymer conformation [Alexandridis and Yang, 2000]. A solvent may enable the dissolution of a certain polymer or cause a polymer to phase separate depending on the interactions between the polymer and the solvent molecules. Addition of a second solvent (cosolvent) in a polymer solution can enhance or reduce the polymer solubility in the solution. An important motivation to consider mixtures of solvents is to enhance the solubility of substances that may be insoluble in a neat solvent [Lin and Alexandridis, 2002]. This is especially applicable in the pharmaceutical industry.
منابع مشابه
Dielectric Constant and Solvent Effect Investigafion on Listeria monoeytogenes In1B-13- sheet Conformation: an Al. initio-NMR study
IniB-the main external virulence factor of the bacterium Listeria monueytogenes- contains seven parallelB-strands at its concave face with a patches of five exposed aromatic amino acids as a hot spot for host receptor(Met) binding. For better understanding of energetic and physicochemical pmpendes, (u)folding transition,binding affinity and makmetic shielding censors of JAB-CRP-II-sheet ab hull...
متن کاملConformation of a polymer chain in solution: an exact density expansion approach.
The conformation of a polymer chain in solution is intrinsically coupled to the thermodynamic and structural properties of the solvent. Here we study such solvent effects in a system consisting of a flexible interaction-site n-mer chain immersed in a monomeric solvent. Chain conformation is described with a set of intramolecular site-site probability functions. We derive an exact density expans...
متن کاملSome X-Ray Studies Concerning the Influence of Solvents on Polypeptide Structures
X-Ray structure determinations have been made of several partially crystalline polypeptide-solvent systems. By comparing these structures with those of the dry polypeptides, an investigation has been made of the effects of solvent incorporation on the conformation and packing of the polypeptide chains. Polyproline I forms two complexes with propionic acid. In one case there are alternating shee...
متن کاملEnergy Study at Different Temperatures for Active Site of Azurin in Water, Ethanol, Methanol and Gas Phase by Monte Carlo Simulations
The interaction between the solute and the solsent molecules play a crucial role in understanding the various molecular processes involved in chemistry and biochemistry, so in this work the potential energy of active site of azurin have been calculated in solvent by the Monte Carlo simulation. In this paper we present quantitative results of Monte Carlo calculations of potential energies of ...
متن کاملAn explicit-solvent conformation search method using open software
Computer modeling is a popular tool to identify the most-probable conformers of a molecule. Although the solvent can have a large effect on the stability of a conformation, many popular conformational search methods are only capable of describing molecules in the gas phase or with an implicit solvent model. We have developed a work-flow for performing a conformation search on explicitly-solvate...
متن کامل